Assay Detail

CHEMBL5514020

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Functional

Anti-inflammatory activity in imiquimod-induced BALB/c mouse psoriasis model assessed as reduction in skin inflammation

ChEMBL ↗

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Target

Mus musculus (CHEMBL375) ↗

Open DB target context

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Mus musculus (CHEMBL375) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Mus musculus

CHEMBL375

Anchored from Assay target.

Protein identity Mus musculus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Confidence	1 — Organism
Curated By	Autocuration

Target

Mus musculus (CHEMBL375) ↗

Type	ORGANISM
Organism	Mus musculus

Publication

Small-molecule agents for treating skin diseases.

Cai H, Wen H, Li J, Lu L, Zhao W, Jiang X, Bai R.
Eur J Med Chem (2024) 268 : 116269 -116269
PubMed 38422702 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4071864	GSK2982772	2.0	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4071864	GSK2982772	EC50	=	4.0	nM	8.40