Assay Detail
Functional
CHEMBL5518286
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Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances of targeting nicotinamide phosphoribosyltransferase (NAMPT) for cancer drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.61 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208619 | — | — | 1 | 9.00 |
| CHEMBL4209341 | — | — | 1 | 9.00 |
| CHEMBL4204004 | — | — | 1 | 8.52 |
| CHEMBL4215840 | — | — | 1 | 8.30 |
| CHEMBL3127521 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208619 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4209341 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4204004 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4215840 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3127521 | — | IC50 | = | 5.7 | nM | 8.24 |