Assay Detail
ADMET
CHEMBL5518319
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Inhibition of CYP3A4 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Strategies of targeting CYP51 for IFIs therapy: Emerging prospects, opportunities and challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.42 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL638 | VORICONAZOLE | 4.0 | 1 | 4.89 |
| CHEMBL3310993 | — | — | 1 | 4.50 |
| CHEMBL3311228 | OTESECONAZOLE | 4.0 | 1 | 4.19 |
| CHEMBL3311227 | — | — | 1 | 4.10 |
| CHEMBL5196919 | — | — | 1 | - |
| CHEMBL3310995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL638 | VORICONAZOLE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3310993 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3311228 | OTESECONAZOLE | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3311227 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL5196919 | — | IC50 | = | 10.0 | ug.mL-1 | - |
| CHEMBL3310995 | — | IC50 | = | 136000.0 | nM | - |