Assay Detail
Functional
CHEMBL5518622
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Antiviral activity against HIV-1 HE infected in wild type human CEM/0 cells assessed as inhibition of virus-induced giant cell formation incubated for 4 to 5 days by light microscopy
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM/0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Membrane-permeable tenofovir-di- and monophosphate analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.47 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 7.89 |
| CHEMBL5566808 | — | — | 1 | 7.46 |
| CHEMBL5550034 | — | — | 1 | 7.33 |
| CHEMBL5557401 | — | — | 1 | 7.21 |
| CHEMBL6067697 | — | — | 1 | 7.14 |
| CHEMBL5560841 | — | — | 1 | 7.11 |
| CHEMBL5555925 | — | — | 1 | 6.82 |
| CHEMBL5558677 | — | — | 1 | 6.80 |
| CHEMBL5557428 | — | — | 1 | 6.44 |
| CHEMBL5559443 | — | — | 1 | 6.41 |
| CHEMBL5558540 | — | — | 1 | 6.35 |
| CHEMBL5563866 | — | — | 1 | 6.34 |
| CHEMBL5561583 | — | — | 1 | 6.19 |
| CHEMBL5542995 | — | — | 1 | 5.95 |
| CHEMBL5562219 | — | — | 1 | 5.91 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.68 |
| CHEMBL5559042 | — | — | 1 | 5.37 |
| CHEMBL5561532 | — | — | 1 | 5.28 |
| CHEMBL5558509 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5566808 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5550034 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5557401 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL6067697 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5560841 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5555925 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5558677 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5557428 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5559443 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5558540 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5563866 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5561583 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5542995 | — | EC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5562219 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL5559042 | — | EC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL5561532 | — | EC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL5558509 | — | EC50 | = | 6960.0 | nM | 5.16 |