Assay Detail
ADMET
CHEMBL5520754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP3A4 incubated for 60 mins by red fluorescent-probe-based microsomal assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.26 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561773 | — | — | 1 | 6.39 |
| CHEMBL3291398 | LEFAMULIN | 4.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561773 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3291398 | LEFAMULIN | IC50 | = | 750.0 | nM | 6.12 |