Assay Detail
Binding
CHEMBL5521990
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Binding affinity to Keap1 (unknown origin) assessed as dissociation constant incubated for 60 mins by fluorescence polarization assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Kelch-like ECH-associated protein 1 (CHEMBL2069156) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cyclic Peptide Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Design, Synthesis, and In Vivo Treatment of Acute Lung Injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 28 | 6.38 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561577 | — | — | 1 | 7.29 |
| CHEMBL5556757 | — | — | 1 | 7.20 |
| CHEMBL5567058 | — | — | 1 | 7.15 |
| CHEMBL3134422 | — | — | 1 | 6.76 |
| CHEMBL5550010 | — | — | 1 | 6.73 |
| CHEMBL5561616 | — | — | 1 | 6.64 |
| CHEMBL5558378 | — | — | 1 | 6.63 |
| CHEMBL5562745 | — | — | 1 | 6.63 |
| CHEMBL5562503 | — | — | 1 | 6.62 |
| CHEMBL5532238 | — | — | 1 | 6.62 |
| CHEMBL5560284 | — | — | 1 | 6.51 |
| CHEMBL5561828 | — | — | 1 | 6.50 |
| CHEMBL5567745 | — | — | 1 | 6.48 |
| CHEMBL5566612 | — | — | 1 | 6.48 |
| CHEMBL5559670 | — | — | 1 | 6.41 |
| CHEMBL5563709 | — | — | 1 | 6.13 |
| CHEMBL5555522 | — | — | 1 | 5.66 |
| CHEMBL5557796 | — | — | 1 | 5.62 |
| CHEMBL5558340 | — | — | 1 | 5.44 |
| CHEMBL5557216 | — | — | 1 | 5.32 |
| CHEMBL5559056 | — | — | 1 | 5.15 |
| CHEMBL5564779 | — | — | 1 | - |
| CHEMBL5559635 | — | — | 1 | - |
| CHEMBL5562630 | — | — | 1 | - |
| CHEMBL5564374 | — | — | 1 | - |
| CHEMBL5568467 | — | — | 1 | - |
| CHEMBL5561543 | — | — | 1 | - |
| CHEMBL5555807 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561577 | — | Kd | = | 51.0 | nM | 7.29 |
| CHEMBL5556757 | — | Kd | = | 63.0 | nM | 7.20 |
| CHEMBL5567058 | — | Kd | = | 71.0 | nM | 7.15 |
| CHEMBL3134422 | — | Kd | = | 172.0 | nM | 6.76 |
| CHEMBL5550010 | — | Kd | = | 185.0 | nM | 6.73 |
| CHEMBL5561616 | — | Kd | = | 229.0 | nM | 6.64 |
| CHEMBL5558378 | — | Kd | = | 232.0 | nM | 6.63 |
| CHEMBL5562745 | — | Kd | = | 235.0 | nM | 6.63 |
| CHEMBL5562503 | — | Kd | = | 237.0 | nM | 6.62 |
| CHEMBL5532238 | — | Kd | = | 238.0 | nM | 6.62 |
| CHEMBL5560284 | — | Kd | = | 306.0 | nM | 6.51 |
| CHEMBL5561828 | — | Kd | = | 313.0 | nM | 6.50 |
| CHEMBL5567745 | — | Kd | = | 334.0 | nM | 6.48 |
| CHEMBL5566612 | — | Kd | = | 328.0 | nM | 6.48 |
| CHEMBL5559670 | — | Kd | = | 386.0 | nM | 6.41 |
| CHEMBL5563709 | — | Kd | = | 747.0 | nM | 6.13 |
| CHEMBL5555522 | — | Kd | = | 2213.0 | nM | 5.66 |
| CHEMBL5557796 | — | Kd | = | 2414.0 | nM | 5.62 |
| CHEMBL5558340 | — | Kd | = | 3618.0 | nM | 5.44 |
| CHEMBL5557216 | — | Kd | = | 4834.0 | nM | 5.32 |
| CHEMBL5559056 | — | Kd | = | 7051.0 | nM | 5.15 |
| CHEMBL5564779 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5559635 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5562630 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5564374 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5568467 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5561543 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5555807 | — | Kd | > | 10000.0 | nM | - |