Compound Detail
CHEMBL5566612
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CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)[C@@H](C)O
Basic Information
| ChEMBL ID | CHEMBL5566612 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PGNGCVJMNTYESM-QJJPRLFZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1089.1
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 6.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kelch-like ECH-associated protein 1 CHEMBL2069156 | Kd | 6.48 | 6.48 | 328.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kelch-like ECH-associated protein 1 | Kd | = | 328.0 | nM | 6.48 | Binding affinity to Keap1 (unknown origin) assessed as dissociation constant inc... | 38485922 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38485922 | 10.1021/acs.jmedchem.4c00065 | Peritoneal macrophage | 2 |
| 38485922 | 10.1021/acs.jmedchem.4c00065 | Kelch-like ECH-associated protein 1 | 1 |
| 38485922 | 10.1021/acs.jmedchem.4c00065 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine