Assay Detail
Functional
CHEMBL5524107
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Agonist activity at human FPR1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.02 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379761 | — | — | 1 | 7.19 |
| CHEMBL5560735 | — | — | 1 | 5.85 |
| CHEMBL4784510 | BMS-986235 | 1.0 | 1 | 5.55 |
| CHEMBL564392 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379761 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5560735 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4784510 | BMS-986235 | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL564392 | — | EC50 | = | 3200.0 | nM | 5.50 |