Compound Detail
CHEMBL564392
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL564392 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IXJJOFFFTXGHHC-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
456.3
MW (Da)
4.11
ALogP
5
HBA
1
HBD
73.2
PSA (Ų)
0.61
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 6 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-formyl peptide receptor 2 CHEMBL4227 | EC50 | 6.22 | 6.22 | 600.0 | 2 |
| fMet-Leu-Phe receptor CHEMBL3359 | EC50 | 6.1 | 5.8 | 800.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-formyl peptide receptor 2 | EC50 | = | 600.0 | nM | 6.22 | Agonist activity at FPRL1 in human neutrophiles assessed as induction of intrace... | 19639995 |
| N-formyl peptide receptor 2 | EC50 | = | 600.0 | nM | 6.22 | Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay | 19639995 |
| fMet-Leu-Phe receptor | EC50 | = | 800.0 | nM | 6.1 | Agonist activity at FPR1 in human neutrophiles assessed as induction of intracel... | 19639995 |
| fMet-Leu-Phe receptor | EC50 | = | 800.0 | nM | 6.1 | Agonist activity at FPR1 in human neutrophiles by chemotaxis assay | 19639995 |
| fMet-Leu-Phe receptor | EC50 | = | 3200.0 | nM | 5.5 | Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of ... | 19639995 |
| fMet-Leu-Phe receptor | EC50 | = | 3200.0 | nM | 5.5 | Agonist activity at human FPR1 | 38199163 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19639995 | 10.1021/jm900592h | fMet-Leu-Phe receptor | 4 |
| 19639995 | 10.1021/jm900592h | N-formyl peptide receptor 2 | 3 |
| 19639995 | 10.1021/jm900592h | N-formyl peptide receptor 3 | 1 |
| 20870313 | 10.1016/j.ejmech.2010.09.001 | fMet-Leu-Phe receptor | 1 |
| 38199163 | 10.1016/j.ejmech.2023.115989 | fMet-Leu-Phe receptor | 1 |
| 38199163 | 10.1016/j.ejmech.2023.115989 | N-formyl peptide receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine