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Assay Detail

CHEMBL5524136

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at FPR2 (unknown origin) in HEK293 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

N-formyl peptide receptor 2 (CHEMBL4227)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists.
Yi X, Tran E, Odiba JO, Qin CX, Ritchie RH, Baell JB.
Eur J Med Chem (2024) 265 : 115989 -115989
PubMed 38199163 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 8.12 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5567819 1 10.15
CHEMBL5563146 1 9.52
CHEMBL5561530 1 9.40
CHEMBL5561111 1 9.15
CHEMBL5561975 1 8.77
CHEMBL5557151 1 8.70
CHEMBL5542471 1 8.52
CHEMBL5560784 1 8.40
CHEMBL5563899 1 8.40
CHEMBL5531970 1 8.40
CHEMBL3915698 1 8.12
CHEMBL4755656 1 8.00
CHEMBL1370052 1 7.82
CHEMBL1289381 1 7.00
CHEMBL1289260 1 6.40
CHEMBL1289811 1 5.68
CHEMBL1290250 1 5.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5567819 EC50 = 0.07 nM 10.15
CHEMBL5563146 EC50 = 0.3 nM 9.52
CHEMBL5561530 EC50 = 0.4 nM 9.40
CHEMBL5561111 EC50 = 0.7 nM 9.15
CHEMBL5561975 EC50 = 1.7 nM 8.77
CHEMBL5557151 EC50 = 2.0 nM 8.70
CHEMBL5542471 EC50 = 3.0 nM 8.52
CHEMBL5560784 EC50 = 4.0 nM 8.40
CHEMBL5563899 EC50 = 4.0 nM 8.40
CHEMBL5531970 EC50 = 4.0 nM 8.40
CHEMBL3915698 EC50 = 7.6 nM 8.12
CHEMBL4755656 EC50 = 10.0 nM 8.00
CHEMBL1370052 EC50 = 15.0 nM 7.82
CHEMBL1289381 EC50 = 100.0 nM 7.00
CHEMBL1289260 EC50 = 400.0 nM 6.40
CHEMBL1289811 EC50 = 2100.0 nM 5.68
CHEMBL1290250 EC50 = 2600.0 nM 5.58