Compound Detail
CHEMBL1289381
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Basic Information
| ChEMBL ID | CHEMBL1289381 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HSUKKJKUETYPHG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
349.2
MW (Da)
3.82
ALogP
2
HBA
2
HBD
50.4
PSA (Ų)
0.86
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-formyl peptide receptor 2 CHEMBL4227 | EC50 | 7.0 | 7.0 | 100.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-formyl peptide receptor 2 | EC50 | = | 100.0 | nM | 7.0 | Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dy... | 25882522 |
| N-formyl peptide receptor 2 | EC50 | = | 100.0 | nM | 7.0 | Agonist activity at FPR2 (unknown origin) in HEK293 cells | 38199163 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20870313 | 10.1016/j.ejmech.2010.09.001 | N-formyl peptide receptor 2 | 1 |
| 25882522 | 10.1016/j.bmc.2015.03.062 | N-formyl peptide receptor 2 | 1 |
| 38199163 | 10.1016/j.ejmech.2023.115989 | N-formyl peptide receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine