Assay Detail
Binding
CHEMBL5524643
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Inhibition of ovine COX-1 by EIA method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.31 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558069 | — | — | 1 | 8.40 |
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | 7.46 |
| CHEMBL600662 | — | — | 1 | 6.83 |
| CHEMBL5532578 | — | — | 1 | 6.78 |
| CHEMBL5567935 | — | — | 1 | 6.61 |
| CHEMBL5561303 | — | — | 1 | 6.41 |
| CHEMBL5561700 | — | — | 1 | 6.01 |
| CHEMBL5562342 | — | — | 1 | 5.87 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.61 |
| CHEMBL5562199 | — | — | 1 | 5.60 |
| CHEMBL5532591 | — | — | 1 | 5.60 |
| CHEMBL5566103 | — | — | 1 | 5.48 |
| CHEMBL5558625 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558069 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL571 | KETOPROFEN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL600662 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL5532578 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL5567935 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL5561303 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL5561700 | — | IC50 | = | 983.0 | nM | 6.01 |
| CHEMBL5562342 | — | IC50 | = | 1355.0 | nM | 5.87 |
| CHEMBL118 | CELECOXIB | IC50 | = | 2447.0 | nM | 5.61 |
| CHEMBL5562199 | — | IC50 | = | 2507.0 | nM | 5.60 |
| CHEMBL5532591 | — | IC50 | = | 2498.0 | nM | 5.60 |
| CHEMBL5566103 | — | IC50 | = | 3282.0 | nM | 5.48 |
| CHEMBL5558625 | — | IC50 | = | 3770.0 | nM | 5.42 |