Assay Detail
Toxicity
CHEMBL5526698
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Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay
46
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Electrophile Determines Cellular Phenotypes among XPO1-Targeting Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 46 | 6.34 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3898452 | — | — | 1 | 8.30 |
| CHEMBL5568605 | — | — | 1 | 8.05 |
| CHEMBL3545185 | SELINEXOR | 4.0 | 1 | 7.77 |
| CHEMBL5560534 | — | — | 1 | 7.64 |
| CHEMBL3545187 | VERDINEXOR | 2.0 | 1 | 7.57 |
| CHEMBL5556912 | — | — | 1 | 7.46 |
| CHEMBL129857 | AS-602868 | 1.0 | 1 | 7.42 |
| CHEMBL5542505 | — | — | 1 | 7.24 |
| CHEMBL5559223 | — | — | 1 | 7.21 |
| CHEMBL5555068 | — | — | 2 | 7.21 |
| CHEMBL5566091 | — | — | 1 | 7.21 |
| CHEMBL5556828 | — | — | 1 | 7.19 |
| CHEMBL5542885 | — | — | 1 | 6.96 |
| CHEMBL5562296 | — | — | 1 | 6.76 |
| CHEMBL5561263 | — | — | 1 | 6.64 |
| CHEMBL5563530 | — | — | 1 | 6.57 |
| CHEMBL5564554 | — | — | 1 | 6.55 |
| CHEMBL5542934 | — | — | 1 | 6.39 |
| CHEMBL130837 | — | — | 1 | 6.39 |
| CHEMBL5563366 | — | — | 1 | 6.35 |
| CHEMBL5561311 | — | — | 1 | 6.32 |
| CHEMBL336546 | — | — | 1 | 6.26 |
| CHEMBL5562376 | — | — | 1 | 6.17 |
| CHEMBL5566432 | — | — | 1 | 6.04 |
| CHEMBL5561442 | — | — | 1 | 6.04 |
| CHEMBL130007 | — | — | 1 | 5.82 |
| CHEMBL5564519 | — | — | 1 | 5.81 |
| CHEMBL5563179 | — | — | 1 | 5.80 |
| CHEMBL5555764 | — | — | 1 | 5.79 |
| CHEMBL5566341 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3898452 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5568605 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3545185 | SELINEXOR | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5560534 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3545187 | VERDINEXOR | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5556912 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL129857 | AS-602868 | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5542505 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5559223 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5566091 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5555068 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5556828 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5555068 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5542885 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5562296 | — | EC50 | = | 174.0 | nM | 6.76 |
| CHEMBL5561263 | — | EC50 | = | 228.0 | nM | 6.64 |
| CHEMBL5563530 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5564554 | — | EC50 | = | 282.0 | nM | 6.55 |
| CHEMBL130837 | — | EC50 | = | 403.0 | nM | 6.39 |
| CHEMBL5542934 | — | EC50 | = | 403.0 | nM | 6.39 |
| CHEMBL5563366 | — | EC50 | = | 443.0 | nM | 6.35 |
| CHEMBL5561311 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL336546 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5562376 | — | EC50 | = | 683.0 | nM | 6.17 |
| CHEMBL5566432 | — | EC50 | = | 912.0 | nM | 6.04 |
| CHEMBL5561442 | — | EC50 | = | 921.0 | nM | 6.04 |
| CHEMBL130007 | — | EC50 | = | 1499.0 | nM | 5.82 |
| CHEMBL5564519 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5563179 | — | EC50 | = | 1583.0 | nM | 5.80 |
| CHEMBL5566341 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL5555764 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL5561373 | — | EC50 | = | 1677.0 | nM | 5.78 |
| CHEMBL5567882 | — | EC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL5565311 | — | EC50 | = | 2613.0 | nM | 5.58 |
| CHEMBL5560350 | — | EC50 | = | 3092.0 | nM | 5.51 |
| CHEMBL424086 | — | EC50 | = | 3484.0 | nM | 5.46 |
| CHEMBL5563183 | — | EC50 | = | 6451.0 | nM | 5.19 |
| CHEMBL5563692 | — | EC50 | = | 6607.0 | nM | 5.18 |
| CHEMBL5564418 | — | EC50 | = | 7614.0 | nM | 5.12 |
| CHEMBL5558576 | — | EC50 | = | 8424.0 | nM | 5.07 |
| CHEMBL5568216 | — | EC50 | = | 12826.0 | nM | 4.89 |
| CHEMBL132495 | — | EC50 | = | 15038.0 | nM | 4.82 |
| CHEMBL5561264 | — | EC50 | = | 25375.0 | nM | 4.60 |
| CHEMBL5560389 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5562070 | — | EC50 | - | — | - | |
| CHEMBL5567104 | — | EC50 | > | 50000.0 | nM | - |