Assay Detail
Functional
CHEMBL5530256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.13 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.16 |
| CHEMBL5574245 | — | — | 1 | 6.96 |
| CHEMBL5565140 | — | — | 1 | 6.57 |
| CHEMBL5555583 | — | — | 1 | 6.52 |
| CHEMBL5573075 | — | — | 1 | 6.50 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | 6.42 |
| CHEMBL5573228 | — | — | 1 | 6.31 |
| CHEMBL5574643 | — | — | 1 | 6.27 |
| CHEMBL5569133 | — | — | 1 | 6.12 |
| CHEMBL5571857 | — | — | 1 | 5.98 |
| CHEMBL5565046 | — | — | 1 | 5.84 |
| CHEMBL5575366 | — | — | 1 | 5.81 |
| CHEMBL5592218 | — | — | 1 | 5.79 |
| CHEMBL5595877 | — | — | 1 | 5.71 |
| CHEMBL5572126 | — | — | 1 | 5.68 |
| CHEMBL5563314 | — | — | 1 | 5.49 |
| CHEMBL5571090 | — | — | 1 | 5.08 |
| CHEMBL5563509 | — | — | 1 | - |
| CHEMBL5557309 | — | — | 1 | - |
| CHEMBL5568977 | — | — | 1 | - |
| CHEMBL5557536 | — | — | 1 | - |
| CHEMBL5574141 | — | — | 1 | - |
| CHEMBL5573142 | — | — | 1 | - |
| CHEMBL5567515 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5574245 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5565140 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5555583 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5573075 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5573228 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5574643 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5569133 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5571857 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5565046 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5575366 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5592218 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL5595877 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL5572126 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5563314 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL5571090 | — | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL5563509 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5557309 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5568977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5557536 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5574141 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5573142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5567515 | — | IC50 | > | 10000.0 | nM | - |