Assay Detail
Binding
CHEMBL5530491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6His tagged FGFR4 (unknown origin) expressed in Escherichia coli (DE3) (NEB) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-Lyte assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.52 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566209 | — | — | 1 | 8.14 |
| CHEMBL5218465 | — | — | 1 | 8.00 |
| CHEMBL5574215 | — | — | 1 | 7.90 |
| CHEMBL5572973 | — | — | 1 | 7.86 |
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 7.82 |
| CHEMBL5574272 | — | — | 1 | 7.79 |
| CHEMBL5574432 | — | — | 1 | 7.72 |
| CHEMBL5573876 | — | — | 1 | 7.71 |
| CHEMBL5592963 | — | — | 1 | 7.70 |
| CHEMBL5593772 | — | — | 1 | 7.69 |
| CHEMBL5573924 | — | — | 1 | 7.69 |
| CHEMBL5572412 | — | — | 1 | 7.67 |
| CHEMBL5569572 | — | — | 1 | 7.66 |
| CHEMBL5573260 | — | — | 1 | 7.65 |
| CHEMBL5570327 | — | — | 1 | 7.64 |
| CHEMBL5570394 | — | — | 1 | 7.63 |
| CHEMBL5572074 | — | — | 1 | 7.61 |
| CHEMBL5569989 | — | — | 1 | 7.59 |
| CHEMBL5567251 | — | — | 1 | 7.58 |
| CHEMBL5572370 | — | — | 1 | 7.57 |
| CHEMBL5573334 | — | — | 1 | 7.53 |
| CHEMBL5568894 | — | — | 1 | 7.52 |
| CHEMBL5557003 | — | — | 1 | 7.47 |
| CHEMBL5583995 | — | — | 1 | 7.41 |
| CHEMBL5574356 | — | — | 1 | 7.40 |
| CHEMBL5543045 | — | — | 1 | 7.25 |
| CHEMBL5573735 | — | — | 1 | 7.05 |
| CHEMBL5571014 | — | — | 1 | 6.93 |
| CHEMBL5568669 | — | — | 1 | 6.93 |
| CHEMBL5570698 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566209 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5218465 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5574215 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL5572973 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL3908979 | FGF401 | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5574272 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL5574432 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL5573876 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL5592963 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5593772 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL5573924 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL5572412 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL5569572 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL5573260 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL5570327 | — | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL5570394 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL5572074 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL5569989 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL5567251 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL5572370 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL5573334 | — | IC50 | = | 29.7 | nM | 7.53 |
| CHEMBL5568894 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL5557003 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5583995 | — | IC50 | = | 39.4 | nM | 7.41 |
| CHEMBL5574356 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL5543045 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL5573735 | — | IC50 | = | 88.9 | nM | 7.05 |
| CHEMBL5571014 | — | IC50 | = | 116.9 | nM | 6.93 |
| CHEMBL5568669 | — | IC50 | = | 117.9 | nM | 6.93 |
| CHEMBL5570698 | — | IC50 | = | 139.8 | nM | 6.85 |
| CHEMBL5573605 | — | IC50 | = | 161.2 | nM | 6.79 |
| CHEMBL5584172 | — | IC50 | = | 179.1 | nM | 6.75 |