Compound Detail
CHEMBL5572074
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Basic Information
| ChEMBL ID | CHEMBL5572074 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MNTRFAOWFMJMKN-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
496.5
MW (Da)
1.15
ALogP
10
HBA
3
HBD
161.8
PSA (Ų)
0.32
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.61
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.61 | 7.61 | 24.5 | 1 |
| Hep 3B2 CHEMBL4296437 | IC50 | 7.19 | 7.19 | 65.1 | 1 |
| BaF3 CHEMBL614524 | IC50 | 6.87 | 6.87 | 134.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 24.5 | nM | 7.61 | Inhibition of N-terminal 6His tagged FGFR4 (unknown origin) expressed in Escheri... | 38348819 |
| Hep 3B2 | IC50 | = | 65.1 | nM | 7.19 | Antiproliferative activity against human Hep3B cells assessed as inhibition of c... | 38348819 |
| BaF3 | IC50 | = | 134.8 | nM | 6.87 | Antiproliferative activity against mouse BaF3 cells harboring wild type FGFR4 as... | 38348819 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38348819 | 10.1021/acs.jmedchem.3c01810 | Fibroblast growth factor receptor 4 | 1 |
| 38348819 | 10.1021/acs.jmedchem.3c01810 | BaF3 | 1 |
| 38348819 | 10.1021/acs.jmedchem.3c01810 | Hep 3B2 | 1 |
Data from ChEMBL 36 via Core Engine