Assay Detail
Functional
CHEMBL5530492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring wild type FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.91 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5593772 | — | — | 1 | 9.70 |
| CHEMBL5569572 | — | — | 1 | 9.22 |
| CHEMBL3939295 | H3B-6527 | 1.0 | 1 | 9.05 |
| CHEMBL5569989 | — | — | 1 | 8.96 |
| CHEMBL5574272 | — | — | 1 | 8.92 |
| CHEMBL5592963 | — | — | 1 | 8.82 |
| CHEMBL5567251 | — | — | 1 | 8.54 |
| CHEMBL5573876 | — | — | 1 | 8.52 |
| CHEMBL5573924 | — | — | 1 | 8.49 |
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 8.40 |
| CHEMBL5572973 | — | — | 1 | 8.22 |
| CHEMBL5570327 | — | — | 1 | 8.14 |
| CHEMBL5574215 | — | — | 1 | 8.12 |
| CHEMBL5572412 | — | — | 1 | 8.11 |
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | 8.04 |
| CHEMBL5573735 | — | — | 1 | 8.00 |
| CHEMBL5218465 | — | — | 1 | 7.93 |
| CHEMBL5566209 | — | — | 1 | 7.90 |
| CHEMBL5557003 | — | — | 1 | 7.77 |
| CHEMBL5584172 | — | — | 1 | 7.52 |
| CHEMBL5573334 | — | — | 1 | 7.52 |
| CHEMBL5583995 | — | — | 1 | 7.44 |
| CHEMBL5568669 | — | — | 1 | 7.42 |
| CHEMBL5570394 | — | — | 1 | 7.41 |
| CHEMBL5572370 | — | — | 1 | 7.36 |
| CHEMBL5543045 | — | — | 1 | 7.33 |
| CHEMBL5573260 | — | — | 1 | 7.20 |
| CHEMBL5574356 | — | — | 1 | 6.92 |
| CHEMBL5572074 | — | — | 1 | 6.87 |
| CHEMBL5573605 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5593772 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5569572 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3939295 | H3B-6527 | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5569989 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5574272 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5592963 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5567251 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5573876 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5573924 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3908979 | FGF401 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5572973 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5570327 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5574215 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5572412 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4514636 | FISOGATINIB | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5573735 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL5218465 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL5566209 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL5557003 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5584172 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL5573334 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL5583995 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5568669 | — | IC50 | = | 38.4 | nM | 7.42 |
| CHEMBL5570394 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5572370 | — | IC50 | = | 43.8 | nM | 7.36 |
| CHEMBL5543045 | — | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL5573260 | — | IC50 | = | 63.4 | nM | 7.20 |
| CHEMBL5574356 | — | IC50 | = | 119.6 | nM | 6.92 |
| CHEMBL5572074 | — | IC50 | = | 134.8 | nM | 6.87 |
| CHEMBL5573605 | — | IC50 | = | 311.3 | nM | 6.51 |
| CHEMBL5568894 | — | IC50 | = | 340.5 | nM | 6.47 |
| CHEMBL5571014 | — | IC50 | = | 518.7 | nM | 6.29 |
| CHEMBL5570698 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5574432 | — | IC50 | < | 0.1 | nM | - |