Assay Detail
Binding
CHEMBL5535105
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Binding affinity to MOR (unknown origin) assessed as inhibition constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.69 | 10.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596 | FENTANYL | 4.0 | 1 | 10.08 |
| CHEMBL982 | NALMEFENE | 4.0 | 1 | 9.52 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596 | FENTANYL | Ki | = | 0.083 | nM | 10.08 |
| CHEMBL982 | NALMEFENE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.33 | nM | 9.48 |