Assay Detail
Functional
CHEMBL5538646
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Antiviral activity against HCoV-OC43 VR-1558 infected in human NCI-H460 cells assessed as inhibition of viral growth incubated for 72 hrs by CCK-8 assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus OC43 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of biaryl amide derivatives against SARS-CoV-2 with dual-target mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 5.30 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650320 | MOLNUPIRAVIR | 3.0 | 1 | 6.75 |
| CHEMBL5572489 | — | — | 1 | 6.00 |
| CHEMBL5572212 | — | — | 1 | 5.96 |
| CHEMBL5566795 | — | — | 1 | 5.91 |
| CHEMBL5594571 | — | — | 1 | 5.91 |
| CHEMBL5573495 | — | — | 1 | 5.75 |
| CHEMBL5591991 | — | — | 1 | 5.73 |
| CHEMBL5568809 | — | — | 1 | 5.70 |
| CHEMBL5565292 | — | — | 1 | 5.67 |
| CHEMBL5071125 | — | — | 1 | 5.61 |
| CHEMBL5590528 | — | — | 1 | 5.61 |
| CHEMBL5087197 | — | — | 1 | 5.60 |
| CHEMBL5572750 | — | — | 1 | 5.59 |
| CHEMBL5567632 | — | — | 1 | 5.58 |
| CHEMBL5593126 | — | — | 1 | 5.55 |
| CHEMBL5572278 | — | — | 1 | 5.53 |
| CHEMBL5077467 | — | — | 1 | 5.53 |
| CHEMBL5070083 | — | — | 1 | 5.53 |
| CHEMBL5595247 | — | — | 1 | 5.51 |
| CHEMBL5573732 | — | — | 1 | 5.50 |
| CHEMBL5076105 | — | — | 1 | 5.45 |
| CHEMBL5085113 | — | — | 1 | 5.43 |
| CHEMBL5572992 | — | — | 1 | 5.42 |
| CHEMBL5089387 | — | — | 1 | 5.41 |
| CHEMBL5091434 | — | — | 1 | 5.39 |
| CHEMBL5570776 | — | — | 1 | 5.38 |
| CHEMBL5570944 | — | — | 1 | 5.35 |
| CHEMBL5071741 | — | — | 1 | 5.27 |
| CHEMBL5083234 | — | — | 1 | 5.24 |
| CHEMBL5575840 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650320 | MOLNUPIRAVIR | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5572489 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5572212 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5566795 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5594571 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5573495 | — | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5591991 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5568809 | — | EC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5565292 | — | EC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5071125 | — | EC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5590528 | — | EC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL5087197 | — | EC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL5572750 | — | EC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5567632 | — | EC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL5593126 | — | EC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL5572278 | — | EC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL5070083 | — | EC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL5077467 | — | EC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5595247 | — | EC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL5573732 | — | EC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL5076105 | — | EC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL5085113 | — | EC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL5572992 | — | EC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL5089387 | — | EC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL5091434 | — | EC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL5570776 | — | EC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL5570944 | — | EC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL5071741 | — | EC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL5083234 | — | EC50 | = | 5740.0 | nM | 5.24 |
| CHEMBL5575840 | — | EC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL5079599 | — | EC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL5086788 | — | EC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL5573710 | — | EC50 | = | 11690.0 | nM | 4.93 |
| CHEMBL5090855 | — | EC50 | = | 12130.0 | nM | 4.92 |
| CHEMBL5573562 | — | EC50 | = | 12050.0 | nM | 4.92 |
| CHEMBL5570590 | — | EC50 | = | 12830.0 | nM | 4.89 |
| CHEMBL5563635 | — | EC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL5079761 | — | EC50 | = | 19170.0 | nM | 4.72 |
| CHEMBL5570371 | — | EC50 | = | 19540.0 | nM | 4.71 |
| CHEMBL5572621 | — | EC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL5573589 | — | EC50 | = | 22220.0 | nM | 4.65 |
| CHEMBL5571230 | — | EC50 | = | 26240.0 | nM | 4.58 |
| CHEMBL5566826 | — | EC50 | = | 27180.0 | nM | 4.57 |
| CHEMBL5574919 | — | EC50 | = | 28630.0 | nM | 4.54 |
| CHEMBL5570982 | — | EC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL5593192 | — | EC50 | = | 41490.0 | nM | 4.38 |
| CHEMBL5570629 | — | EC50 | > | 3130.0 | nM | - |
| CHEMBL5592322 | — | EC50 | > | 3130.0 | nM | - |
| CHEMBL5085426 | — | EC50 | > | 66670.0 | nM | - |
| CHEMBL5595507 | — | EC50 | > | 1560.0 | nM | - |