Assay Detail
Functional
CHEMBL5539619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mGlu3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, Pharmacology, and In Silico Studies of (1<i>S</i>,2<i>S</i>,3<i>S</i>)-2-((<i>S</i>)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu<sub>2</sub> Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.23 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334160 | — | — | 1 | 7.42 |
| CHEMBL280563 | — | — | 1 | 6.22 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334160 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL280563 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 9000.0 | nM | 5.05 |