Assay Detail
Binding
CHEMBL5541677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR1 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP measured after 60 mins by fluorescence-based microfluidic mobility shift assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Piperazinyl-Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.11 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571836 | — | — | 1 | 8.47 |
| CHEMBL5572540 | — | — | 1 | 8.42 |
| CHEMBL5570514 | — | — | 1 | 8.42 |
| CHEMBL5572826 | — | — | 1 | 8.24 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.24 |
| CHEMBL5575774 | — | — | 1 | 7.82 |
| CHEMBL5093894 | — | — | 1 | 7.66 |
| CHEMBL5570406 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571836 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5572540 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5570514 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5572826 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5575774 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL5093894 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5570406 | — | IC50 | = | 24.2 | nM | 7.62 |