Compound Detail
CHEMBL5570514
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CN1CCN([C@H]2CC(F)(F)c3cc(NC(=O)c4ccc(F)c(C#Cc5cncc(N6CCC6)c5)c4)ccc32)CC1
Basic Information
| ChEMBL ID | CHEMBL5570514 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YZRLWPBYTMKRQR-LJAQVGFWSA-N |
11
Targets
11
Activities
1
Assay Types
0
PK Parameters
18
Publications
0
Known Names
Molecular Properties
545.6
MW (Da)
4.87
ALogP
5
HBA
1
HBD
51.7
PSA (Ų)
0.47
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 11 meas. best 8.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.42 | 8.42 | 3.8 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Platelet-derived growth factor receptor alpha CHEMBL2007 | IC50 | 8.26 | 8.26 | 5.5 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 8.12 | 8.12 | 7.5 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.05 | 8.05 | 8.9 | 1 |
| Discoidin domain-containing receptor 2 CHEMBL5122 | IC50 | 7.91 | 7.91 | 12.4 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.79 | 7.79 | 16.1 | 1 |
| Tyrosine-protein kinase ABL1 CHEMBL1862 | IC50 | 7.68 | 7.68 | 20.9 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 7.61 | 7.61 | 24.3 | 1 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 7.03 | 7.03 | 94.1 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.43 | 6.43 | 368.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine