Assay Detail
ADMET
CHEMBL5541945
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Inhibition of CYP3A4 (unknown origin) using testosterone as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Nivasorexant (ACT-539313): The First Selective Orexin-1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.89 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3917550 | — | — | 1 | 5.48 |
| CHEMBL3981385 | — | — | 1 | 5.11 |
| CHEMBL5573198 | — | — | 1 | 4.60 |
| CHEMBL3951681 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3917550 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3981385 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5573198 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3951681 | — | IC50 | = | 43000.0 | nM | 4.37 |