Assay Detail
Functional
CHEMBL5543319
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Anti-inflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production pre-treated with compounds for 2 hrs followed by LPS-stimulation measured for 22 hrs by Griess reagent based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.11 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571374 | — | — | 1 | 5.65 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | 5.28 |
| CHEMBL5568775 | — | — | 1 | 5.23 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 5.02 |
| CHEMBL5569304 | — | — | 1 | 4.96 |
| CHEMBL5572751 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571374 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL5568775 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5569304 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL5572751 | — | IC50 | = | 29200.0 | nM | 4.54 |