Assay Detail
Binding
CHEMBL5543877
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Inhibition of ovine COX-1 by colorimetric assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.29 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL5569084 | — | — | 1 | 5.44 |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 5.42 |
| CHEMBL5565667 | — | — | 1 | 5.39 |
| CHEMBL5564555 | — | — | 1 | 5.22 |
| CHEMBL5591853 | — | — | 1 | 5.16 |
| CHEMBL2234942 | — | — | 1 | 5.13 |
| CHEMBL5564416 | — | — | 1 | 5.06 |
| CHEMBL5579684 | — | — | 1 | 5.01 |
| CHEMBL5574361 | — | — | 1 | 4.95 |
| CHEMBL5566175 | — | — | 1 | 4.91 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5569084 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5565667 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL5564555 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL5591853 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL2234942 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL5564416 | — | IC50 | = | 8670.0 | nM | 5.06 |
| CHEMBL5579684 | — | IC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL5574361 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL5566175 | — | IC50 | = | 12230.0 | nM | 4.91 |
| CHEMBL118 | CELECOXIB | IC50 | = | 14700.0 | nM | 4.83 |