Assay Detail
Binding
CHEMBL5543896
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Inhibition of ovine COX-1 by colorimetric assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.92 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | 4.0 | 1 | 8.10 |
| CHEMBL5573862 | — | — | 1 | 7.34 |
| CHEMBL5567378 | — | — | 1 | 7.28 |
| CHEMBL4462870 | — | — | 1 | 7.12 |
| CHEMBL5572914 | — | — | 1 | 7.10 |
| CHEMBL5572619 | — | — | 1 | 6.92 |
| CHEMBL5572292 | — | — | 1 | 6.92 |
| CHEMBL5569710 | — | — | 1 | 6.64 |
| CHEMBL5573040 | — | — | 1 | 6.50 |
| CHEMBL5579661 | — | — | 1 | 6.35 |
| CHEMBL5571714 | — | — | 1 | 5.89 |
| CHEMBL5563480 | — | — | 1 | - |
| CHEMBL5574653 | — | — | 1 | - |
| CHEMBL5593821 | — | — | 1 | - |
| CHEMBL5583683 | — | — | 1 | - |
| CHEMBL5573058 | — | — | 1 | - |
| CHEMBL5571322 | — | — | 1 | - |
| CHEMBL5591112 | — | — | 1 | - |
| CHEMBL5563326 | — | — | 1 | - |
| CHEMBL5591549 | — | — | 1 | - |
| CHEMBL5564783 | — | — | 1 | - |
| CHEMBL5569519 | — | — | 1 | - |
| CHEMBL5570107 | — | — | 1 | - |
| CHEMBL5575442 | — | — | 1 | - |
| CHEMBL5595152 | — | — | 1 | - |
| CHEMBL5564448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5573862 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5567378 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4462870 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5572914 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5572619 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5572292 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5569710 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5573040 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5579661 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5571714 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5563480 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5574653 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5593821 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5583683 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5573058 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5571322 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5591112 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5563326 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5591549 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5564783 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5569519 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5570107 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5575442 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5595152 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5564448 | — | IC50 | > | 50000.0 | nM | - |