Assay Detail
Binding
CHEMBL5544029
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Inhibition of mushroom tyrosinase diphenolase activity using L-dopa as substrate incubated for 0.5 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
In vitro and in vivo anti-pigmentation effects of 2-mercaptobenzimidazoles as nanomolar tyrosinase inhibitors on mammalian cells and zebrafish embryos: Preparation of pigment-free zebrafish embryos.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.80 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575470 | — | — | 1 | 7.70 |
| CHEMBL69086 | — | — | 1 | 7.52 |
| CHEMBL5594681 | — | — | 1 | 7.40 |
| CHEMBL5566100 | — | — | 1 | 7.16 |
| CHEMBL1509639 | — | — | 1 | 7.10 |
| CHEMBL1726268 | — | — | 1 | 7.05 |
| CHEMBL4857118 | — | — | 1 | 7.00 |
| CHEMBL70141 | 2-MERCAPTOBENZIMIDAZOLE | — | 1 | 6.82 |
| CHEMBL1359012 | — | — | 1 | 6.16 |
| CHEMBL4879224 | — | — | 1 | 6.13 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575470 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL69086 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5594681 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5566100 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1509639 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1726268 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4857118 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL70141 | 2-MERCAPTOBENZIMIDAZOLE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1359012 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4879224 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 19520.0 | nM | 4.71 |