Compound Detail
CHEMBL1509639
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1509639 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KOFBRZWVWJCLGM-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
180.2
MW (Da)
1.86
ALogP
3
HBA
2
HBD
37.9
PSA (Ų)
0.66
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mushroom tyrosinase CHEMBL6066154 | IC50 | 7.1 | 6.925 | 80.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mushroom tyrosinase | IC50 | = | 80.0 | nM | 7.1 | Inhibition of mushroom tyrosinase diphenolase activity using L-dopa as substrate... | 38244374 |
| Mushroom tyrosinase | IC50 | = | 180.0 | nM | 6.75 | Inhibition of mushroom tyrosinase monophenolase activity using L-tyrosine as sub... | 38244374 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 38244374 | 10.1016/j.ejmech.2024.116136 | Mushroom tyrosinase | 2 |
| 38244374 | 10.1016/j.ejmech.2024.116136 | Danio rerio | 2 |
| 38244374 | 10.1016/j.ejmech.2024.116136 | No relevant target | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 33894528 | 10.1016/j.ejmech.2021.113455 | Proteasome subunit beta type-8 | 1 |
| - | 10.6019/EOS300041 | Replicase polyprotein 1ab | 1 |
| - | 10.6019/EOS300044 | Replicase polyprotein 1ab | 1 |
| 38244374 | 10.1016/j.ejmech.2024.116136 | Tyrosinase | 1 |
Data from ChEMBL 36 via Core Engine