Assay Detail
Binding
CHEMBL5544510
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Inhibition of human FAAH by fluorescence-based cayman assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel dual-target FAAH and TRPV1 ligands as potential pharmacotherapeutics for pain management.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 5.59 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184238 | URB-597 | 1.0 | 1 | 7.44 |
| CHEMBL5576003 | — | — | 1 | 6.92 |
| CHEMBL5562683 | — | — | 1 | 6.35 |
| CHEMBL5569813 | — | — | 1 | 6.29 |
| CHEMBL5565868 | — | — | 1 | 5.97 |
| CHEMBL5573187 | — | — | 1 | 5.91 |
| CHEMBL5567412 | — | — | 1 | 5.90 |
| CHEMBL5583922 | — | — | 1 | 5.88 |
| CHEMBL5564392 | — | — | 1 | 5.88 |
| CHEMBL5568875 | — | — | 1 | 5.74 |
| CHEMBL5592635 | — | — | 1 | 5.70 |
| CHEMBL5574803 | — | — | 1 | 5.69 |
| CHEMBL5569079 | — | — | 1 | 5.69 |
| CHEMBL5575387 | — | — | 1 | 5.66 |
| CHEMBL5595759 | — | — | 1 | 5.62 |
| CHEMBL5595034 | — | — | 1 | 5.54 |
| CHEMBL5570886 | — | — | 1 | 5.52 |
| CHEMBL5575114 | — | — | 1 | 5.50 |
| CHEMBL5574957 | — | — | 1 | 5.48 |
| CHEMBL582459 | — | — | 1 | 5.47 |
| CHEMBL5571224 | — | — | 1 | 5.46 |
| CHEMBL5566759 | — | — | 1 | 5.42 |
| CHEMBL5591234 | — | — | 1 | 5.37 |
| CHEMBL5572535 | — | — | 1 | 5.37 |
| CHEMBL5570863 | — | — | 1 | 5.36 |
| CHEMBL5593757 | — | — | 1 | 5.36 |
| CHEMBL5592512 | — | — | 1 | 5.31 |
| CHEMBL5566902 | — | — | 1 | 5.30 |
| CHEMBL5567326 | — | — | 1 | 5.29 |
| CHEMBL5591606 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184238 | URB-597 | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5576003 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5562683 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5569813 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5565868 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5573187 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL5567412 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL5583922 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5564392 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5568875 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL5592635 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5574803 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5569079 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5575387 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL5595759 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL5595034 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL5570886 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5575114 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL5574957 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL582459 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL5571224 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL5566759 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL5591234 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL5572535 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5593757 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL5570863 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL5592512 | — | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL5566902 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL5567326 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL5591606 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL5567186 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL5591375 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL5570509 | — | IC50 | = | 6370.0 | nM | 5.20 |
| CHEMBL5566109 | — | IC50 | = | 6470.0 | nM | 5.19 |
| CHEMBL3326390 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL5564915 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL5569620 | — | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL5573946 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL191534 | — | IC50 | = | 9450.0 | nM | 5.03 |
| CHEMBL5572351 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5570438 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5567044 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5571589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5572581 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5574855 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5569204 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5564684 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5566423 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5574300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL441472 | — | IC50 | > | 10000.0 | nM | - |