Compound Detail
CHEMBL5572535
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Basic Information
| ChEMBL ID | CHEMBL5572535 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SFACAEWPTRJVTF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
469.0
MW (Da)
5.01
ALogP
3
HBA
4
HBD
95.2
PSA (Ų)
0.39
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | IC50 | 6.63 | 6.63 | 234.4 | 1 |
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 5.37 | 5.37 | 4310.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 234.4 | nM | 6.63 | Antagonist activity at human TRPV1 receptor assessed as inhibition of TRPV1 chan... | 38325006 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 4310.0 | nM | 5.37 | Inhibition of human FAAH by fluorescence-based cayman assay | 38325006 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38325006 | 10.1016/j.ejmech.2024.116208 | Transient receptor potential cation channel subfamily V member 1 | 1 |
| 38325006 | 10.1016/j.ejmech.2024.116208 | Fatty-acid amide hydrolase 1 | 1 |
Data from ChEMBL 36 via Core Engine