Assay Detail
Functional
CHEMBL5544643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human muscarinic M1 receptor expressed in CHO cells incubated for 10 mins in presence of acetylcholine by inositol 1-phosphate accumulation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Activity Evaluation of Fluorine-Containing Scopolamine Analogues as Potential Antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.28 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569713 | SCOPOLAMINE | 4.0 | 1 | 8.73 |
| CHEMBL5575342 | — | — | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569713 | SCOPOLAMINE | IC50 | = | 1.85 | nM | 8.73 |
| CHEMBL5575342 | — | IC50 | = | 14.62 | nM | 7.83 |