Assay Detail
Binding
CHEMBL5548922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha (unknown origin) by ADP-glo plus luminescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.21 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 8.22 |
| CHEMBL5566586 | — | — | 1 | 7.99 |
| CHEMBL5572519 | — | — | 1 | 7.92 |
| CHEMBL5573179 | — | — | 1 | 7.82 |
| CHEMBL5573982 | — | — | 1 | 7.66 |
| CHEMBL5575213 | — | — | 1 | 7.42 |
| CHEMBL5568655 | — | — | 1 | 7.36 |
| CHEMBL5568982 | — | — | 1 | 7.34 |
| CHEMBL5570389 | — | — | 1 | 7.34 |
| CHEMBL5594441 | — | — | 1 | 7.19 |
| CHEMBL5566351 | — | — | 1 | 7.12 |
| CHEMBL5567165 | — | — | 1 | 6.95 |
| CHEMBL5573450 | — | — | 1 | 6.79 |
| CHEMBL5574430 | — | — | 1 | 6.63 |
| CHEMBL5576014 | — | — | 1 | 6.61 |
| CHEMBL5572006 | — | — | 1 | 6.59 |
| CHEMBL5568986 | — | — | 1 | 6.45 |
| CHEMBL5575995 | — | — | 1 | 6.42 |
| CHEMBL5564044 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5566586 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL5572519 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL5573179 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL5573982 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL5575213 | — | IC50 | = | 38.4 | nM | 7.42 |
| CHEMBL5568655 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5568982 | — | IC50 | = | 45.4 | nM | 7.34 |
| CHEMBL5570389 | — | IC50 | = | 45.4 | nM | 7.34 |
| CHEMBL5594441 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5566351 | — | IC50 | = | 75.4 | nM | 7.12 |
| CHEMBL5567165 | — | IC50 | = | 112.3 | nM | 6.95 |
| CHEMBL5573450 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL5574430 | — | IC50 | = | 232.3 | nM | 6.63 |
| CHEMBL5576014 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL5572006 | — | IC50 | = | 256.1 | nM | 6.59 |
| CHEMBL5568986 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL5575995 | — | IC50 | = | 378.6 | nM | 6.42 |
| CHEMBL5564044 | — | IC50 | > | 10000.0 | nM | - |