Assay Detail
Functional
CHEMBL5548932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.60 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568986 | — | — | 1 | 6.13 |
| CHEMBL5590918 | — | — | 1 | 6.11 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 6.01 |
| CHEMBL5572519 | — | — | 1 | 5.95 |
| CHEMBL5573982 | — | — | 1 | 5.74 |
| CHEMBL5568982 | — | — | 1 | 5.68 |
| CHEMBL5564044 | — | — | 1 | 5.65 |
| CHEMBL5573450 | — | — | 1 | 5.63 |
| CHEMBL5575407 | — | — | 1 | 5.61 |
| CHEMBL5566586 | — | — | 1 | 5.53 |
| CHEMBL5573179 | — | — | 1 | 5.32 |
| CHEMBL5575534 | — | — | 1 | 5.30 |
| CHEMBL5576014 | — | — | 1 | 5.00 |
| CHEMBL5594441 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568986 | — | IC50 | = | 732.0 | nM | 6.13 |
| CHEMBL5590918 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5572519 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5573982 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL5568982 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL5564044 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL5573450 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL5575407 | — | IC50 | = | 2451.0 | nM | 5.61 |
| CHEMBL5566586 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL5573179 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5575534 | — | IC50 | = | 5052.0 | nM | 5.30 |
| CHEMBL5576014 | — | IC50 | = | 10040.0 | nM | 5.00 |
| CHEMBL5594441 | — | IC50 | = | 17480.0 | nM | 4.76 |