Assay Detail

CHEMBL5550334

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Functional

Antiproliferative activity against human A2780 cells

ChEMBL ↗

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Target

A2780 (CHEMBL614004) ↗

Open DB target context

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A2780 (CHEMBL614004) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target A2780

CHEMBL614004

Anchored from Assay target.

Protein identity A2780

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A2780
Confidence	1 — Organism
Curated By	Autocuration

Target

A2780 (CHEMBL614004) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives.

Wen F, Gui G, Wang X, Ye L, Qin A, Zhou C, Zha X.
Bioorg Med Chem (2024) 99 : 117595 -117595
PubMed 38244254 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.92	6.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3105156	—	—	1	6.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3105156	—	IC50	=	120.0	nM	6.92