Assay Detail
Binding
CHEMBL5550419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human Haspin kinase domain (470 to 798 residues) expressed in bacteria using histone H3 (1 to 21) peptide as substrate incubated for 30 mins in presence of ATP by ADP-Glo kinase assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase haspin (CHEMBL1075163) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.95 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178368 | — | — | 1 | 8.70 |
| CHEMBL5181620 | — | — | 1 | 7.30 |
| CHEMBL5594716 | — | — | 1 | 7.21 |
| CHEMBL5569099 | — | — | 1 | 7.12 |
| CHEMBL5570490 | — | — | 1 | 7.12 |
| CHEMBL5563473 | — | — | 1 | 6.94 |
| CHEMBL5574139 | — | — | 1 | 6.91 |
| CHEMBL5562930 | — | — | 1 | 6.89 |
| CHEMBL5592689 | — | — | 1 | 6.82 |
| CHEMBL5571626 | — | — | 1 | 6.80 |
| CHEMBL5564481 | — | — | 1 | 6.80 |
| CHEMBL5574327 | — | — | 1 | 6.61 |
| CHEMBL5563580 | — | — | 1 | 6.60 |
| CHEMBL5569713 | — | — | 1 | 6.32 |
| CHEMBL5574287 | — | — | 1 | 6.09 |
| CHEMBL5595643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178368 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5181620 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5594716 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5569099 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5570490 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5563473 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL5574139 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL5562930 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5592689 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5571626 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5564481 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5574327 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5563580 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL5569713 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL5574287 | — | IC50 | = | 819.0 | nM | 6.09 |
| CHEMBL5595643 | — | IC50 | ~ | 1000.0 | nM | - |