Compound Detail
CHEMBL5569713
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Basic Information
| ChEMBL ID | CHEMBL5569713 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JVYZNTURNUEHAL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
244.3
MW (Da)
4.38
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.53
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase haspin CHEMBL1075163 | IC50 | 6.32 | 6.32 | 482.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase haspin | IC50 | = | 482.0 | nM | 6.32 | Inhibition of recombinant human Haspin kinase domain (470 to 798 residues) expre... | 38320389 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38320389 | 10.1016/j.bmc.2024.117619 | Serine/threonine-protein kinase haspin | 3 |
| 38320389 | 10.1016/j.bmc.2024.117619 | Dual specificity protein kinase CLK1 | 2 |
| 38320389 | 10.1016/j.bmc.2024.117619 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2 |
| 38320389 | 10.1016/j.bmc.2024.117619 | CDK9/cyclin T1 | 2 |
| 38320389 | 10.1016/j.bmc.2024.117619 | Glycogen synthase kinase-3 beta | 2 |
| 38320389 | 10.1016/j.bmc.2024.117619 | Casein kinase I isoform epsilon | 2 |
| 38320389 | 10.1016/j.bmc.2024.117619 | Cyclin-dependent kinase 5/CDK5 activator 1 | 2 |
| 38320389 | 10.1016/j.bmc.2024.117619 | Serine/threonine-protein kinase pim-1 | 2 |
Data from ChEMBL 36 via Core Engine