Assay Detail
Functional
CHEMBL5550829
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Antiviral activity against HCoV-OC43 infected in human Huh-7 cells assessed as reduction in cytopathic effect pretreated with cells followed by viral infection and measured after 7 days
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus OC43 |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.65 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 6.96 |
| CHEMBL5565685 | — | — | 1 | 6.92 |
| CHEMBL5565858 | — | — | 1 | 6.55 |
| CHEMBL5570210 | — | — | 1 | 6.54 |
| CHEMBL5595277 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5565685 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5565858 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5570210 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5595277 | — | EC50 | = | 550.0 | nM | 6.26 |