Assay Detail
Functional
CHEMBL5551474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at TGR5 (unknown origin) in CHO-K1 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
G-protein coupled bile acid receptor 1 (CHEMBL5409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Update on the development of TGR5 agonists for human diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.87 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391533 | COROSOLIC ACID | — | 1 | 6.30 |
| CHEMBL201515 | MASLINIC ACID | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391533 | COROSOLIC ACID | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL201515 | MASLINIC ACID | EC50 | = | 3700.0 | nM | 5.43 |