Assay Detail
Binding
CHEMBL5552296
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Binding affinity to human N-terminal his tagged Hsp90beta (1 to 239 residues) expressed in Escherichia coli (DE3) strain assessed as dissociation constant by Fluorescent thermal shift assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comprehensive analysis of resorcinyl-imidazole Hsp90 inhibitor design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 32 | 5.67 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574581 | — | — | 1 | 8.70 |
| CHEMBL5569309 | — | — | 1 | 8.40 |
| CHEMBL5564393 | — | — | 1 | 8.30 |
| CHEMBL5568823 | — | — | 1 | 7.96 |
| CHEMBL5562891 | — | — | 1 | 6.36 |
| CHEMBL5570148 | — | — | 1 | 5.77 |
| CHEMBL5563338 | — | — | 1 | 5.75 |
| CHEMBL5574005 | — | — | 1 | 5.47 |
| CHEMBL5565341 | — | — | 1 | 5.33 |
| CHEMBL5567226 | — | — | 1 | 5.27 |
| CHEMBL5573532 | — | — | 1 | 5.26 |
| CHEMBL5571438 | — | — | 1 | 5.26 |
| CHEMBL5573792 | — | — | 1 | 5.22 |
| CHEMBL5562627 | — | — | 1 | 5.17 |
| CHEMBL5574513 | — | — | 1 | 5.16 |
| CHEMBL5566352 | — | — | 1 | 5.10 |
| CHEMBL5564811 | — | — | 1 | 5.10 |
| CHEMBL5574697 | — | — | 1 | 5.02 |
| CHEMBL5572196 | — | — | 1 | 5.00 |
| CHEMBL5595824 | — | — | 1 | 4.92 |
| CHEMBL5573452 | — | — | 1 | 4.77 |
| CHEMBL5571855 | — | — | 1 | 4.34 |
| CHEMBL5573001 | — | — | 1 | 4.24 |
| CHEMBL5567036 | — | — | 1 | 4.10 |
| CHEMBL5570869 | — | — | 1 | - |
| CHEMBL5571440 | — | — | 1 | - |
| CHEMBL5579749 | — | — | 1 | - |
| CHEMBL5569544 | — | — | 1 | - |
| CHEMBL5569716 | — | — | 1 | - |
| CHEMBL5564920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574581 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL5569309 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL5564393 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL5568823 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL5562891 | — | Kd | = | 440.0 | nM | 6.36 |
| CHEMBL5570148 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL5563338 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL5574005 | — | Kd | = | 3400.0 | nM | 5.47 |
| CHEMBL5565341 | — | Kd | = | 4700.0 | nM | 5.33 |
| CHEMBL5567226 | — | Kd | = | 5400.0 | nM | 5.27 |
| CHEMBL5573532 | — | Kd | = | 5500.0 | nM | 5.26 |
| CHEMBL5571438 | — | Kd | = | 5500.0 | nM | 5.26 |
| CHEMBL5573792 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL5562627 | — | Kd | = | 6800.0 | nM | 5.17 |
| CHEMBL5574513 | — | Kd | = | 6900.0 | nM | 5.16 |
| CHEMBL5564811 | — | Kd | = | 7900.0 | nM | 5.10 |
| CHEMBL5566352 | — | Kd | = | 7900.0 | nM | 5.10 |
| CHEMBL5574697 | — | Kd | = | 9500.0 | nM | 5.02 |
| CHEMBL5572196 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL5595824 | — | Kd | = | 12000.0 | nM | 4.92 |
| CHEMBL5573452 | — | Kd | = | 17000.0 | nM | 4.77 |
| CHEMBL5571855 | — | Kd | = | 46000.0 | nM | 4.34 |
| CHEMBL5573001 | — | Kd | = | 57000.0 | nM | 4.24 |
| CHEMBL5567036 | — | Kd | = | 79000.0 | nM | 4.10 |
| CHEMBL5570869 | — | Kd | >= | 200000.0 | nM | - |
| CHEMBL5571440 | — | Kd | >= | 200000.0 | nM | - |
| CHEMBL5579749 | — | Kd | >= | 200000.0 | nM | - |
| CHEMBL5569544 | — | Kd | >= | 200000.0 | nM | - |
| CHEMBL5569716 | — | Kd | >= | 200000.0 | nM | - |
| CHEMBL5564920 | — | Kd | >= | 200000.0 | nM | - |
| CHEMBL5575085 | — | Kd | >= | 200000.0 | nM | - |
| CHEMBL5573512 | — | Kd | >= | 200000.0 | nM | - |