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Assay Detail

CHEMBL5576847

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Binding
Inhibition of tyrosine kinase (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Publication

The role of the methoxy group in approved drugs.
Chiodi D, Ishihara Y.
Eur J Med Chem (2024) 273 : 116364 -116364
PubMed 38781921 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.47 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL131725 1 9.10
CHEMBL288441 BOSUTINIB 4.0 1 8.92
CHEMBL100651 1 8.37
CHEMBL101917 1 7.52
CHEMBL339743 1 6.72
CHEMBL167033 1 6.70
CHEMBL166797 1 6.50
CHEMBL340177 1 5.92
CHEMBL354736 1 -
CHEMBL352716 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL131725 IC50 = 0.8 nM 9.10
CHEMBL288441 BOSUTINIB IC50 = 1.2 nM 8.92
CHEMBL100651 IC50 = 4.3 nM 8.37
CHEMBL101917 IC50 = 30.0 nM 7.52
CHEMBL339743 IC50 = 190.0 nM 6.72
CHEMBL167033 IC50 = 200.0 nM 6.70
CHEMBL166797 IC50 = 320.0 nM 6.50
CHEMBL340177 IC50 = 1200.0 nM 5.92
CHEMBL354736 IC50 > 1000.0 nM -
CHEMBL352716 IC50 > 1000.0 nM -