Assay Detail
Binding
CHEMBL5576918
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Inhibition of mushroom tyrosinase using L-DOPA as substrate by spectrophotometric analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3-hydroxyquinolin-2(1H)-one derivatives as inhibitors of tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.25 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743159 | — | — | 1 | 6.89 |
| CHEMBL2386734 | — | — | 1 | 5.60 |
| CHEMBL150372 | 3-HYDROXYCOUMARIN | — | 1 | 5.60 |
| CHEMBL146227 | — | — | 1 | 5.56 |
| CHEMBL509045 | — | — | 1 | 5.45 |
| CHEMBL495022 | — | — | 1 | 5.21 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.58 |
| CHEMBL5591878 | — | — | 1 | 4.36 |
| CHEMBL495187 | — | — | 1 | 4.03 |
| CHEMBL502372 | — | — | 1 | - |
| CHEMBL5589676 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743159 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2386734 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL150372 | 3-HYDROXYCOUMARIN | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL146227 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL509045 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL495022 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL5591878 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL495187 | — | IC50 | = | 92700.0 | nM | 4.03 |
| CHEMBL502372 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL5589676 | — | IC50 | = | 926000.0 | nM | - |