Compound Detail
CHEMBL2386734
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2386734 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MTGIZESTAZZBMV-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
240.1
MW (Da)
2.00
ALogP
2
HBA
2
HBD
53.1
PSA (Ų)
0.74
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mushroom tyrosinase CHEMBL6066154 | IC50 | 5.6 | 5.6 | 2520.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.13 | 5.13 | 7400.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mushroom tyrosinase | IC50 | = | 2520.0 | nM | 5.6 | Inhibition of mushroom tyrosinase using L-DOPA as substrate by spectrophotometri... | 38823727 |
| Unchecked | IC50 | = | 7400.0 | nM | 5.13 | Inhibition of H1N1 Influenza A endonuclease after 1 hr by fluorescence assay | 24936242 |
| Unchecked | IC50 | = | 7400.0 | nM | 5.13 | Endonuclease Assay: The PAN domain has been shown to cleave ssRNA as well as ssD... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24936242 | 10.1021/ml4001112 | HEK293 | 1 |
| 24936242 | 10.1021/ml4001112 | MDCK | 1 |
| 24936242 | 10.1021/ml4001112 | Unchecked | 1 |
| 38823727 | 10.1016/j.bmcl.2024.129823 | Mushroom tyrosinase | 1 |
Data from ChEMBL 36 via Core Engine