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Assay Detail

CHEMBL5578999

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Hemolytic activity against human RBC incubated for 1 hr by microplate reader analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type Erythrocyte
Confidence 1 — Organism
Curated By Autocuration

Target

Erythrocyte (CHEMBL4296518)
Type CELL-LINE

Publication

Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities.
Deb R, Torres MDT, Boudný M, Koběrská M, Cappiello F, Popper M, Dvořáková Bendová K, Drabinová M, Hanáčková A, Jeannot K, Petřík M, Mangoni ML, Balíková Novotná G, Mráz M, de la Fuente-Nunez C, Vácha R.
J Med Chem (2024) 67 : 14040 -14061
PubMed 39116273 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.17 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL174 AMPICILLIN 4.0 1 6.05
CHEMBL5590171 1 5.16
CHEMBL5592498 1 4.31
CHEMBL5592838 1 -
CHEMBL5590515 1 -
CHEMBL5594404 1 -
CHEMBL5590247 1 -
CHEMBL5594680 1 -
CHEMBL5591216 1 -
CHEMBL5593137 1 -
CHEMBL5595754 1 -
CHEMBL5593337 1 -
CHEMBL5595052 1 -
CHEMBL5592285 1 -
CHEMBL5594579 1 -
CHEMBL5591279 1 -
CHEMBL5593135 1 -
CHEMBL5590497 1 -
CHEMBL5584167 1 -
CHEMBL5583887 1 -
CHEMBL5590306 1 -
CHEMBL5594932 1 -
CHEMBL5592715 1 -
CHEMBL5592279 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL174 AMPICILLIN IC50 = 900.0 nM 6.05
CHEMBL5590171 IC50 = 6900.0 nM 5.16
CHEMBL5592498 IC50 = 49000.0 nM 4.31
CHEMBL5592838 IC50 > 50000.0 nM -
CHEMBL5590515 IC50 > 50000.0 nM -
CHEMBL5594404 IC50 > 50000.0 nM -
CHEMBL5590247 IC50 > 50000.0 nM -
CHEMBL5594680 IC50 > 50000.0 nM -
CHEMBL5591216 IC50 > 50000.0 nM -
CHEMBL5593137 IC50 > 50000.0 nM -
CHEMBL5595754 IC50 > 50000.0 nM -
CHEMBL5593337 IC50 > 50000.0 nM -
CHEMBL5595052 IC50 > 50000.0 nM -
CHEMBL5592285 IC50 > 50000.0 nM -
CHEMBL5594579 IC50 > 50000.0 nM -
CHEMBL5591279 IC50 > 50000.0 nM -
CHEMBL5593135 IC50 > 50000.0 nM -
CHEMBL5590497 IC50 > 50000.0 nM -
CHEMBL5584167 IC50 > 50000.0 nM -
CHEMBL5583887 IC50 > 50000.0 nM -
CHEMBL5590306 IC50 > 50000.0 nM -
CHEMBL5594932 IC50 > 50000.0 nM -
CHEMBL5592715 IC50 > 50000.0 nM -
CHEMBL5592279 IC50 > 50000.0 nM -