Assay Detail
Binding
CHEMBL5579285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-AMPA from AMPA in rat brain membrane preincubated for 15 mins followed by [3H]-AMPA addition and measured after 40 mins by scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.97 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5589739 | — | — | 1 | 5.44 |
| CHEMBL5594753 | — | — | 1 | 5.24 |
| CHEMBL482097 | DOMORIC ACID | — | 1 | 4.92 |
| CHEMBL5590005 | — | — | 1 | 4.77 |
| CHEMBL5589717 | — | — | 1 | 4.50 |
| CHEMBL5593727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5589739 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5594753 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL482097 | DOMORIC ACID | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5590005 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5589717 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5593727 | — | IC50 | > | 100000.0 | nM | - |