Compound Detail
CHEMBL5589739
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Basic Information
| ChEMBL ID | CHEMBL5589739 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OEHDXJSAUSRUGS-XDTMEGJNSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
313.4
MW (Da)
1.20
ALogP
4
HBA
4
HBD
123.9
PSA (Ų)
0.50
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
| Glutamate receptor 4 CHEMBL3505 | IC50 | 5.44 | 5.44 | 3600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 9.0 | nM | 8.05 | Displacement of [3H]-Kainic acid from KA in rat brain membrane preincubated for ... | 39133077 |
| Glutamate receptor 4 | IC50 | = | 3600.0 | nM | 5.44 | Displacement of [3H]-AMPA from AMPA in rat brain membrane preincubated for 15 mi... | 39133077 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39133077 | 10.1021/acs.jmedchem.4c01311 | Glutamate receptor 4 | 1 |
| 39133077 | 10.1021/acs.jmedchem.4c01311 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine