Assay Detail
Toxicity
CHEMBL5579429
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Cytotoxicity against human Hepatocyte cultured as 3D spheroids incubated for 14 days by CellTiter-Glo luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.17 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5590333 | — | — | 1 | 5.60 |
| CHEMBL5595336 | — | — | 1 | 5.20 |
| CHEMBL1720448 | — | — | 1 | 4.70 |
| CHEMBL5591147 | — | — | 1 | - |
| CHEMBL5592276 | — | — | 1 | - |
| CHEMBL5584184 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5590333 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5595336 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1720448 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5591147 | — | IC50 | < | 1200.0 | nM | - |
| CHEMBL5592276 | — | IC50 | < | 1200.0 | nM | - |
| CHEMBL5584184 | — | IC50 | < | 1200.0 | nM | - |