Compound Detail
CHEMBL5584184
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Basic Information
| ChEMBL ID | CHEMBL5584184 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DXZQACFEAZEKNY-HWRSSNJWSA-N |
1
Targets
3
Activities
1
Assay Types
5
PK Parameters
3
Publications
0
Known Names
Molecular Properties
355.5
MW (Da)
3.44
ALogP
4
HBA
3
HBD
80.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 8.0 | 7.79 | 10.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 12.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 38.0 | mL.min-1.kg-1 | Mus musculus |
| CL | 30.0 | mL.min-1.kg-1 | Mus musculus |
| F | 62.0 | % | Mus musculus |
| MRT | 3.0 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 10.0 | nM | 8.0 | Inhibition of STT3A/STT3B mediated N-linked glycosylation in STT3B knockout huma... | 39136957 |
| Unchecked | EC50 | = | 15.0 | nM | 7.82 | Inhibition of STT3A/STT3B mediated N-linked glycosylation in human H1-HeLa cells... | 39136957 |
| Unchecked | EC50 | = | 28.0 | nM | 7.55 | Inhibition of STT3A/STT3B mediated N-linked glycosylation in STT3A knockout huma... | 39136957 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39136957 | 10.1021/acs.jmedchem.4c01402 | Unchecked | 11 |
| 39136957 | 10.1021/acs.jmedchem.4c01402 | ADMET | 8 |
| 39136957 | 10.1021/acs.jmedchem.4c01402 | Hepatocyte | 1 |
Data from ChEMBL 36 via Core Engine