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Assay Detail

CHEMBL5580700

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of equine BuChE
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL5763)
Type SINGLE PROTEIN
Organism Equus caballus

Publication

New insights into butyrylcholinesterase: Pharmaceutical applications, selective inhibitors and multitarget-directed ligands.
Sun T, Zhen T, Harakandi CH, Wang L, Guo H, Chen Y, Sun H.
Eur J Med Chem (2024) 275 : 116569 -116569
PubMed 38852337 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.69 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5593808 1 8.15
CHEMBL5592608 1 8.00
CHEMBL5593372 2 7.40
CHEMBL5589755 1 7.24
CHEMBL5594084 1 7.08
CHEMBL5595293 1 6.96
CHEMBL5594827 1 6.75
CHEMBL118752 1 6.57
CHEMBL5595800 1 6.28
CHEMBL5592518 1 6.10
CHEMBL5590165 1 6.00
CHEMBL4241871 1 6.00
CHEMBL5220690 1 5.36
CHEMBL5592197 1 5.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5593808 IC50 = 7.0 nM 8.15
CHEMBL5592608 IC50 = 10.0 nM 8.00
CHEMBL5593372 IC50 = 40.0 nM 7.40
CHEMBL5593372 IC50 = 46.0 nM 7.34
CHEMBL5589755 IC50 = 57.0 nM 7.24
CHEMBL5594084 IC50 = 84.0 nM 7.08
CHEMBL5595293 IC50 = 110.0 nM 6.96
CHEMBL5594827 IC50 = 180.0 nM 6.75
CHEMBL118752 IC50 = 270.0 nM 6.57
CHEMBL5595800 IC50 = 530.0 nM 6.28
CHEMBL5592518 IC50 = 800.0 nM 6.10
CHEMBL5590165 IC50 = 990.0 nM 6.00
CHEMBL4241871 IC50 = 1000.0 nM 6.00
CHEMBL5220690 IC50 = 4330.0 nM 5.36
CHEMBL5592197 IC50 = 7330.0 nM 5.13