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Assay Detail

CHEMBL5583400

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of equine serum BuChE by microplate reader based analysis
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL5763) ↗
Type SINGLE PROTEIN
Organism Equus caballus

Publication

Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases.
Nocentini A, Costa A, Bonardi A, Ammara A, Giovannuzzi S, Petreni A, Bartolucci G, Rani B, Leri M, Bucciantini M, Fernández-Bolaños JG, López Ó, Passani MB, Provensi G, Gratteri P, Supuran CT.
J Med Chem (2024) 67 : 16873 -16898
PubMed 39283654 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 9.01 10.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5592238 — — 1 10.32
CHEMBL5595714 — — 1 10.19
CHEMBL5584158 — — 1 10.14
CHEMBL5591456 — — 1 10.04
CHEMBL5589708 — — 1 9.96
CHEMBL5591443 — — 1 9.80
CHEMBL5591515 — — 1 9.80
CHEMBL5592375 — — 1 9.68
CHEMBL5584117 — — 1 9.68
CHEMBL6067717 — — 1 9.66
CHEMBL5590009 — — 1 9.66
CHEMBL5592671 — — 1 9.60
CHEMBL3343930 — — 1 9.59
CHEMBL5592059 — — 1 9.54
CHEMBL5594751 — — 1 9.52
CHEMBL5591886 — — 1 9.48
CHEMBL5595828 — — 1 9.47
CHEMBL5593766 — — 1 9.47
CHEMBL5594120 — — 1 9.42
CHEMBL5591581 — — 1 9.36
CHEMBL5594353 — — 1 9.30
CHEMBL5593853 — — 1 9.24
CHEMBL4596889 — — 1 9.00
CHEMBL3343931 — — 1 8.92
CHEMBL4596300 — — 1 8.80
CHEMBL5593963 — — 1 8.72
CHEMBL5590645 — — 1 8.70
CHEMBL5595724 — — 1 8.62
CHEMBL4594657 — — 1 8.62
CHEMBL5594305 — — 1 8.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5592238 — IC50 = 0.048 nM 10.32
CHEMBL5595714 — IC50 = 0.064 nM 10.19
CHEMBL5584158 — IC50 = 0.073 nM 10.14
CHEMBL5591456 — IC50 = 0.091 nM 10.04
CHEMBL5589708 — IC50 = 0.11 nM 9.96
CHEMBL5591443 — IC50 = 0.16 nM 9.80
CHEMBL5591515 — IC50 = 0.16 nM 9.80
CHEMBL5592375 — IC50 = 0.21 nM 9.68
CHEMBL5584117 — IC50 = 0.21 nM 9.68
CHEMBL6067717 — IC50 = 0.22 nM 9.66
CHEMBL5590009 — IC50 = 0.22 nM 9.66
CHEMBL5592671 — IC50 = 0.25 nM 9.60
CHEMBL3343930 — IC50 = 0.26 nM 9.59
CHEMBL5592059 — IC50 = 0.29 nM 9.54
CHEMBL5594751 — IC50 = 0.3 nM 9.52
CHEMBL5591886 — IC50 = 0.33 nM 9.48
CHEMBL5595828 — IC50 = 0.34 nM 9.47
CHEMBL5593766 — IC50 = 0.34 nM 9.47
CHEMBL5594120 — IC50 = 0.38 nM 9.42
CHEMBL5591581 — IC50 = 0.44 nM 9.36
CHEMBL5594353 — IC50 = 0.5 nM 9.30
CHEMBL5593853 — IC50 = 0.57 nM 9.24
CHEMBL4596889 — IC50 = 1.0 nM 9.00
CHEMBL3343931 — IC50 = 1.2 nM 8.92
CHEMBL4596300 — IC50 = 1.6 nM 8.80
CHEMBL5593963 — IC50 = 1.9 nM 8.72
CHEMBL5590645 — IC50 = 2.0 nM 8.70
CHEMBL5595724 — IC50 = 2.4 nM 8.62
CHEMBL4594657 — IC50 = 2.4 nM 8.62
CHEMBL5594305 — IC50 = 2.5 nM 8.60
CHEMBL5583687 — IC50 = 2.7 nM 8.57
CHEMBL5595013 — IC50 = 2.7 nM 8.57
CHEMBL5590046 — IC50 = 2.8 nM 8.55
CHEMBL5593787 — IC50 = 3.6 nM 8.44
CHEMBL5593714 — IC50 = 3.8 nM 8.42
CHEMBL95 TACRINE IC50 = 3.9 nM 8.41
CHEMBL5594590 — IC50 = 4.0 nM 8.40
CHEMBL5592360 — IC50 = 4.1 nM 8.39
CHEMBL5591427 — IC50 = 4.2 nM 8.38
CHEMBL5591157 — IC50 = 4.4 nM 8.36
CHEMBL5593856 — IC50 = 5.2 nM 8.28
CHEMBL5593657 — IC50 = 5.8 nM 8.24
CHEMBL5593375 — IC50 = 6.8 nM 8.17
CHEMBL5595789 — IC50 = 9.5 nM 8.02
CHEMBL659 GALANTAMINE IC50 = 4683.0 nM 5.33
CHEMBL5592735 — IC50 > 15.3 nM -
CHEMBL90 HISTAMINE IC50 - — -
CHEMBL379630 D-PHENYLALANINE IC50 - — -
CHEMBL301523 PHENYLALANINE IC50 - — -