Assay Detail
Binding
CHEMBL5584715
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SERT expressed in HEK293 cells assessed as reduction in 5-HT reuptake incubated for 30 mins by fluorescent dye uptake assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT<sub>1A</sub>/5-HT<sub>7</sub>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.30 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598106 | — | — | 1 | 9.07 |
| CHEMBL5597217 | — | — | 1 | 9.07 |
| CHEMBL5598295 | — | — | 1 | 8.72 |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.04 |
| CHEMBL4434876 | — | — | 1 | 6.60 |
| CHEMBL5597179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598106 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL5597217 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL5598295 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL549 | CITALOPRAM | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4434876 | — | IC50 | = | 251.1 | nM | 6.60 |
| CHEMBL5597179 | — | IC50 | > | 10000.0 | nM | - |